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Patients following plant-based diets, older adults, or those with a history of gastrointestinal surgery face higher risk

DOI: 10.3389/fpubh.2022.996179

Discacciati, A., Orsini, N

A recent trial examining the effect of the SGLT-2i ipragliflozin in Japanese people with obesity revealed similar mean reductions of fat mass and total lean mass of 1.8 kg and 1.7 kg, respectively, including a small but significant 0.6 kg loss in appendicular lean mass (a good marker of skeletal muscle mass), suggesting that SGLT-2is may induce catabolism of both body fat and muscle secondary to glycosuria [36]